Reaction Rule
Action
Replace
Remove
Add
FlipSkeletonAtom
RemoveSideSkeleton
AttachSideSkeleton
CondenseSkeletonAndAddSegmentAsSideChain
First Functional Group
Primary
Secondary
Tertiary
Agnostic
Specific
HeteroAtom
(1-formylethyl)
Carboxylic Acid
Carboxylic Acid Conjugate Base
Carbothioic S-Acid
Carboxylate ester
Acyl Chloride
Acyl Bromide
Amide
Phosphate
Nitrile
Aldehyde
Thioaldehyde
Ketone
Thione
Alcohol
Thiol
Amine
Imine
PhopsphorylAmine
carbon-carbon double bond
Ester
Ether
Fluoride
Chloride
Bromide
Iodide
Heteroatom Nitrogen
Heteroatom Oxygen
Heteroatom Phosphorous
Nitrite
Thioether
carbon-carbon triple bond
Action Location
FirstOnly
All
NextCarbon
FirstAtomOfFunctionalGroup
BenzeneRing
NextCarbonInBenzeneRing
FirstAvailableCarbon
PiBondCarbon
Second Functional Group
Primary
Secondary
Tertiary
Agnostic
Specific
HeteroAtom
(1-formylethyl)
Carboxylic Acid
Carboxylic Acid Conjugate Base
Carbothioic S-Acid
Carboxylate ester
Acyl Chloride
Acyl Bromide
Amide
Phosphate
Nitrile
Aldehyde
Thioaldehyde
Ketone
Thione
Alcohol
Thiol
Amine
Imine
PhopsphorylAmine
carbon-carbon double bond
Ester
Ether
Fluoride
Chloride
Bromide
Iodide
Heteroatom Nitrogen
Heteroatom Oxygen
Heteroatom Phosphorous
Nitrite
Thioether
carbon-carbon triple bond